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Its ability to protect and regenerate the mucosal lining, reduce inflammation, and improve local blood flow makes it relevant across a spectrum of digestive disorders and gut dysfunctions

76,77 In summary, disc cells respond to altered loads and osmotic pressures, to DAMPs, MMPs and pro-inflammatory cytokines with the expression of catabolic enzymes, with anabolic healing attempts, and with inflammation resulting in failed healing attempts, damage accumulation and chronic inflammation leading eventually to DD

The argument can be made that large scientific studies are expensive, and no company is going to spend the money to conduct these studies on natural supplements for which a patent cannot be obtained

There has not been a UL (upper intake level) established for B12 because it is not stored in your body and therefore, can not build up enough to cause serious adverse side effects for most people